Acalypha indica (English: Indian acalypha, Indian nettle, three-seeded mercury) Hindi: खोकली is a species of plant having catkin type of inflorescence. It occurs throughout tropical Africa and South Africa, in India and Sri Lanka, as well as in Yemen and Pakistan.
The juice is extracted from the leaves, mixed with lime and applied on skin to cure diseases caused by Ringworm. Fresh juice of leaves mixed with oil and salt is used for rheumatoid arthritis and to cure scabies. Powdered leaves are used to cure bedsores and infected wounds. Active medicinal compounds like acalyphine and triacetoneamine are extracted from this plant.They contain cyanogenic glucoside and alkaloids. The paste of the leaves can be applied to burns to treat them.
ACALYPHA INDICA, Linn.
Or A. Spicata or A. Ciliata or A. Canescana, (N. O.—Euphorbiaceae)
Sanskrit: Arittamanjarie.
English: Indian acalypha.
Hindi: Kuppu; Khokali. खोकली
Bengali: Muktajhuri; Sveta-basanta.
Gujurati: Vanchi Kanto.
Mab.—Khokli: Khajoti.
Telugu: Kuppichettu; Harita-manjiri; Kuppinta or Muripindi.
Tamil: Kuppivaeni; Kuppaimeni.
Can.—Kuppigida.
Malayalam: Kuppamani.
Kon.: Kunkmiphal.
Oriya: Indramaris.
Sinb: Kupa-menya.
Habitat: Common annual shrub in Indian gardens, backyards of houses and waste place throughout the plains of India.
Parts Used - Leaves, root, stalks (young shoots) and flowers.
Constituents — Alkaaloids “acalypus” and “acalyphine.”
Action – Cathartic, Anthelmintic, expectorant, emetic, anodyne and hypnotic.
Other Uses:
1. Post-coital antifertility activity of Acalypha indica L.
Four successive solvent extracts of the whole plant Acalypha indica L. (Euphorbiaceae) were tested for post-coital antifertility activity in female albino rats. Of these, the petroleum ether and ethanol extracts were found to be most effective in causing significant anti-implantation activity. The antifertility activity was reversible on withdrawal of the treatment of the extracts. Both the extracts at 600 mg/kg body weight showed estrogenic activity. Histological studies of the uterus were carried out to confirm this estrogenic activity.
2. Council of the Pharmaceutical Society of Great Britain
Acalypha is an irritant to the gastro-intestinal mucous membrane. It is used as a substitute for ipecacuanha. The drug acts reflexly through the stomach in small doses; it also acts as an expectorant arid, in larger doses, as an emetic. This drug has also been used as a laxative and anthelmintic.
3. Antimicrobial activity of extracts of Acalypha indica Linn.
Dilution method was employed to determine the effect of petroleum ether extract (40-60 Degree) chloroform and methanolic extract of dried leaves of Acalypha indica Linn (Euphorbiaceae) against fungi (Candida albicans) and bacteria (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhosa, Bacillus substilis, Klebsiella pneumoniae). Except the petroleum ether extract, all the extract exhibited a prominent antimicrobial activity. The methanolic extract was further fractionated into acetone soluble and insoluble parts. Both the parts exhibited prominent antimicrobial activity. The acetone insoluble part exhibited MIC of 0.0040 mg/ml against Staphylococcus aureus and both acetone soluble and insolube parts exhibited MIC of 0.05 mg/ml against Salmonella typhosa.
4. Wound healing effect of Acalypha indica in rats.
The ethanolic extracts of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica were evaluated for their wound healing activity in rats. Wound healing activity was studied using excision and incision wound models in rats following topical application. Animals were divided into four groups with six in each group. Ten percent w/v extract of each plant was prepared in saline for topical application. H. indicum possesses better wound healing activity than P. zeylanicum and A. indica. Tensile strength results indicate better activity of H. indicum on remodeling phase of wound healing.
5. Acalypha indica in Homeopathy:
A drug having a marked action on the alimentary canal and respiratory organs. It is indicated in incipient phthisis, with hard, racking cough, bloody expectoration, arterial hemorrhage, but no febrile disturbance. Very weak in the morning, gains strength during day. Progressive emaciation. All pathological hemorrhages having notably a morning worse.
6. Acalypha indica in Ayurveda:
Preparations - Infusion of root, powder, decoction, cataplasm, succus (juice expressed), tincture and liquid extract.
Uses –:
Leaves possess laxative properties; “are used as a substitute for senega”; are used in the form of powder or decoction; Mixed with garlic they are used as Anthelmintic in worms. Mixed with garlic they are applied to scabies; and their juice mixed with oil forms an application in rheumatic arthritis.
Expressed juice of the leaves is a safe, certain and speedy emetic for children in one teaspoonful (I drachm) doses, in cases of croup; in smaller doses it is expectorant, and is useful in chronic bronchitis, asthma and consumption. The decoction is employed in ear-ache as instillation and also as fomentation round the aching ear; and a cataplasm of the bruised leaves is applied to syphilitic ulcers, to maggot-eaten sores and also to relieve the pain of snakebites. “juice from fresh leaves may be employed in scabies and other skin diseases, and with lime and onion it is a good stimulating application in rheumatism.
Powder of dry leaves is used in bed sores.
In congestive headache a piece of cotton saturated with the expressed juice of the plant or leaves and inserted into each nostril is said to relieve it by ‘causing hemorrhage from the nose.
In cases of obstinate constipation of children the leaves ground into a paste and made into a ball and introduced into the rectum, relax the sphincter ani and produces free motions. An infusion of the root or the root bruised in water, acts as a cathartic.
Uses in Siddha Medicine:
Properties:
Taste (Suvai) → Bitter, Kaarpu.
Effect during digestion (Veeriyam) → Kaarpu.
Post digestive taste (Pirivu) → Kaarpu
Actions:
Anodyne
Anthelmintic
Cathartic
Diuretic
Emetic
Expectorant
Emmenagogue
Therapeutic properties:
According to the Siddha text, ‘Pathartha Guna Chinthamani’ (Page no:179), Acalypha cures diseases of the teeth and gums, burns, toxins of Plant and mixed origin, stomach pain, diseases due to Pitha, bleeding piles, irritations, stabbing pain, wheezing, sinusitis and neutralizes predominance of the Kabha factor.
According to Siddha Materia Medica8 the leaf powder when given in the dose of 950 mg to 1300 mgs, cures repiratory diseases. The leaf juice when mixed with neem oil and applied to the inner part of children’s tongue with the help of quill, induces vomiting and acts as expectorant.
When the Acalypha leaves in moderate, prescribed quantity is taken along with diet, it removes Thimir Vaatham from the body. When the leaves are fried up with castor oil and given in the prescribed quantity and method for 45 days (mandalam), it removes disastrous Kapha diseases, combined with Vayu (gas) and produces good health.
For removing the toxin arising out of Rat bite, the leaves of Acalypha in the size of areca nut is mixed with water and given for 3 days (with salt restricted diet). But it produces vomiting and diarrhoea also.
